COPD Clinical Trials

COPD (Chronic Obstructive Pulmonary Disease) Study

ClinicalTrials.gov identifier NCT05037929

Brief Summary:

This study will test an investigational drug in addition to standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or current smokers and have a history of frequent exacerbations.

The Immunologic, Metabolic and Extracellular Vesicle Response to Exercise in COPD

This study aims to determine the effects on metabolism and immunity of single acute bout of exercise and of completing a pulmonary rehabilitation program in COPD patients compared with age-matched controls. Exercise capacity, muscle mass, muscle strength and power, resting metabolic rate and fatty acid oxidation will also be measured.

Supported by the NIH REACT Center for rehabilitation research.

And the Tobacco Related Disease Research Program: https://www.trdrp.org/

Determinants of 5-year Progression of Muscle Dysfunction and Inactivity in COPD

This study will measure muscle oxidative capacity and physical activity in COPD patients, 5-years after a previous assessment, and generate models to predict patients who decline rapidly.

Supported by the ATS Foundation: https://foundation.thoracic.org/

COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using ‘Omics Approaches

This study aims to identify why some COPD patients lose muscle mass, while others maintain it. In particular it will investigate the effects of iron metabolism on mitochondrial function in skeletal muscle in COPD patients with and without unintentional weight loss.

Supported by the NIH, National Heart Lung and Blood Institute: https://www.nhlbi.nih.gov/

Wearable Sensors to Monitor Exacerbation Risk In COPD

This study, in collaboration with engineers at Caltech, aims to develop a wearable sensor to identify risk factors for acute COPD exacerbations by sampling sweat from the skin. Patients with stable COPD and hospital in-patients with acute exacerbation of COPD are being enrolled

Supported by the Tobacco Related Disease Research Program: https://www.trdrp.org/

The Role of Systemic Mitochondrial Dysfunction in COPD and Cardiovascular Disease Risk

COPD patients are at greater risk for developing cardiovascular disease than smokers without COPD. This study aims identify whether impaired mitochondrial function, a key consumer of blood-borne lipids, contributes to the link between COPD and cardiovascular disease in the form of coronary artery atherosclerosis.

Supported by the Tobacco Related Disease Research Program: https://www.trdrp.org/

The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

ClinicalTrials.gov identifier NCT00608764

External Link: http://www.copdgene.org/

This nationwide multicenter study aims to identify the genetics behind why some smokers get COPD and other do not. The study is still open to enrollment, but only of participants who have never smoked.

Make an appointment for a private evaluation, at no cost to you, at our research center located on the campus of Harbor/UCLA Medical Center in Torrance, CA