The High-Resolution Respirometry (HRR) Core supports investigators in mitochondrial physiology and pathophysiology studies. The core provides consultation, training, and services for assessment of oxidative phosphorylation in isolated mitochondria, cells, vesicles or tissue preparations. The HRR Core uses Oroboros Oxygraph-2k High Resolution Respirometry and Fluorometry equipment. Applications of HRR include: (1) diagnosis of acquired and genetic mitochondrial diseases, myopathies, and neuromuscular pathologies, (2) study of pathologies with reduced cellular respiration, (3) studies on cell function and cell death, (4) aging and senescence, (5) oxidative stress and antioxidant systems, (6) ischemia-reperfusion injury, (7) cancer research / pharmacological tests, (8) environmental stress, and (9) metabolic substrate balance.
High-Resolution Respirometry (HRR)
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